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AKA: glucosamine sulfate, glucosamine HCL
What Is Glucosamine
Glucosamine is a naturally occurring amino sugar which is a building block for proteins of the connective tissue known as glycosaminoglycans. Around 50% of hyaline cartilage, which covers the bones of the synovial joints such as the knee, hip and shoulder, is composed of these glycosaminoglycans. Cartilage works to absorb shock and reduce friction during movement. Two supplemental types of glucosamine exist: sulfate and hydrochloride.
What It Does
The availability of glucosamine is believed to be a restricting factor in the synthesis of glycosaminoglycan. Therefore, supplementation can avoid the degeneration and loss of cartilage in joints like the knee, hip, ankle, shoulder, and spine. It may also act by suppressing the expression of several mediators of cartilage degradation.
Performance & Health Benefits For Athletes
Many athletes experience persistent joint pain as an effect of training. The physical demands of sport and daily training location a significant quantity of stress on joints. Furthermore, many sportsmen must defeat common injuries to joints resulting in operation or joint reconstruction. Healing from these types of surgeries can lead to changes to the joint, and glucosamine could have a positive influence on recovery.
A large amount of research has been conducted related to glucosamine with mixed results, making it difficult to come to clear conclusions. Nevertheless, most scientists agree that it can improve symptoms of pain associated with osteoarthritis and delay its progress. It appears that long term supplementation over at least 1 year may be required before major progress take place.
In 2005 Poolsup and colleagues reviewed a number of research studies and concluded there was evidence to support improvement of symptoms with glucosamine sulphate. Despite this another number of researchers were more cautious, saying that entire, it was only demonstrated to truly have a moderate clinically significant effect.
Early research work indicated that glucosamine sulfate was superior to HCL in providing advantage, but some experts believe both are equally successful. Just one known research study has used glucosamine after an injury. This trial, which used athletes who had merely suffered knee injuries, supplemented glucosamine for 4 weeks. No differences in malady, swelling, or passive knee flexion and extension were noticed at 7, 14, or 21 days. Yet, after 28 days of supplementation, the group taking the supplements demonstrated significant improvement in passive knee flexion and extension.
Recently, scientists have suggested that a 1500 mg dose is comparatively little compared to higher comparative quantities used in successful animal studies. Some believe this is among the reasons for mixed results in previous research trials. In some European countries and the United Kingdom, the supplement is prescribed as a pharmaceutical drug to deal with osteoarthritis. Yet, not all nations are as convinced of its own effectiveness.
It is best to ask you doctor if they recommend you start supplementing and what dosage to take.
Glucosamine is generally regarded to be safe for consumption by most medical experts. Some recent concerns have been raised in relation to it’s impact on blood glucose levels, glucose metabolism and insulin sensitivity. While it is worth keeping an eye on it this concern is mostly unwarranted due to a lack of strong evidance.
Always consult you doctor or a suitable health professional before taking any new supplement product.